在所有生命科学中，基因组学是最具活力的领域之一。在过去的20年里，我们探索人类基因组的结构、功能和进化的能力急剧上升，由于技术的进步，包括下一代测序，现在可以对基因变体进行绘图和编辑。在寻求确定我们基因组的改变如何直接影响疾病和健康的过程中，基因组学也正在引领一场医疗保健的革命，它让我们更好地了解药物如何对人产生不同的影响，从而使重点、有效的治疗或 “个体化医疗 “成为可能。在基因组医学这个总称下，涵盖了许多不同的领域。我们研究转录组–代表特定生物体或特定细胞类型在某一特定时间点上活跃的基因的RNA分子的总集合。转录组的变化既能反映也能导致疾病，如癌症。我们还考虑 “表观基因组”，即对细胞中的DNA和DNA相关蛋白的可遗传的化学修饰，这些修饰改变了基因表达，是自然发育和组织分化的结果，也是对疾病或环境暴露的反应。在这两种情况下，我们寻求确定这些变化如何直接影响疾病和健康状况。你将学习最近的技术进步如何改变了基因组数据的生成、分析和展示方式；生物信息学如何使我们能够处理和理解大数据及其对整个医疗保健的影响。在此过程中，你将考虑它与一系列临床场景的相关性，如特定感染在医院间的传播、COVID-19大流行，以及对靶向治疗反应的生物标志物的识别。这个硕士学位由伦敦圣乔治大学授予，与伦敦大学国王学院合作教学。你将受益于这两所院校的联合教学和研究专长，以及这两所院校提供的全面和专业的资源，因为这两所院校都是专业的卫生大学，也是英国最顶尖的两所研究大学。学习基因组医学有助于为日常医疗或临床实践提供信息，让你更好地了解什么是致病原因和疾病的影响，这对广大卫生专业人员来说是很有意义的。你可以选择学习单个模块、PgCert、PgDip或完整的MSc，这可以导致一系列的职业，包括在NHS、制药业和生物信息学，或者为博士生提供准备。
基因组学医学
Genomics Medicine
专业介绍
在所有生命科学中，基因组学是最具活力的领域之一。在过去的20年里，我们探索人类基因组的结构、功能和进化的能力急剧上升，由于技术的进步，包括下一代测序，现在可以对基因变体进行绘图和编辑。在寻求确定我们基因组的改变如何直接影响疾病和健康的过程中，基因组学也正在引领一场医疗保健的革命，它让我们更好地了解药物如何对人产生不同的影响，从而使重点、有效的治疗或 "个体化医疗 "成为可能。在基因组医学这个总称下，涵盖了许多不同的领域。我们研究转录组--代表特定生物体或特定细胞类型在某一特定时间点上活跃的基因的RNA分子的总集合。转录组的变化既能反映也能导致疾病，如癌症。我们还考虑 "表观基因组"，即对细胞中的DNA和DNA相关蛋白的可遗传的化学修饰，这些修饰改变了基因表达，是自然发育和组织分化的结果，也是对疾病或环境暴露的反应。在这两种情况下，我们寻求确定这些变化如何直接影响疾病和健康状况。你将学习最近的技术进步如何改变了基因组数据的生成、分析和展示方式；生物信息学如何使我们能够处理和理解大数据及其对整个医疗保健的影响。在此过程中，你将考虑它与一系列临床场景的相关性，如特定感染在医院间的传播、COVID-19大流行，以及对靶向治疗反应的生物标志物的识别。这个硕士学位由伦敦圣乔治大学授予，与伦敦大学国王学院合作教学。你将受益于这两所院校的联合教学和研究专长，以及这两所院校提供的全面和专业的资源，因为这两所院校都是专业的卫生大学，也是英国最顶尖的两所研究大学。学习基因组医学有助于为日常医疗或临床实践提供信息，让你更好地了解什么是致病原因和疾病的影响，这对广大卫生专业人员来说是很有意义的。你可以选择学习单个模块、PgCert、PgDip或完整的MSc，这可以导致一系列的职业，包括在NHS、制药业和生物信息学，或者为博士生提供准备。
Program Introduction
Of all the life sciences, genomics is one of the most dynamic areas. The
past 20 years have seen an explosion in our ability to explore the
structure, function and evolution of the human genome, with mapping and
editing of gene variants now possible due to technological advances,
including next-generation sequencing.
In seeking to identify how alterations to our genomes directly affect
disease and health, genomics is also leading a revolution in healthcare
by giving a better understanding of how drugs affect people differently
and thus allowing for focused, effective, treatment or ‘personalised
medicine’.
Under the umbrella term of genomic medicine, there are many different
areas that are covered. We look at the transcriptome – the total set of
RNA molecules which represents the genes active in a given organism or
particular cell type at a given point in time. Changes to the
transcriptome can both reflect and cause diseases such as cancer.
We also consider the ‘epigenome’, heritable chemical modifications to
DNA and DNA-associated proteins in the cell, which alter gene expression
as a result of natural development and tissue differentiation or in
response to disease or environmental exposures. In both instances, we
seek to identify how these changes directly affect disease and ill
health.
You will learn how recent technological advances have transformed how
genomic data is generated, analysed and presented; how bioinformatics is
enabling us to handle and make sense of big data and its impact across
healthcare. In doing so, you will consider its relevance to a range of
clinical scenarios, such as the spread of specific infections across
hospitals, the COVID-19 pandemic, and identification of biomarkers of
response to targeted therapies.
This master’s degree, awarded by St George’s University of London, is
taught in partnership with King’s College London. You will benefit from
the combined teaching and research expertise, and the comprehensive and
specialist resources provided by these two institutions, as both
specialist health universities, and two of the UK’s top research
universities.
Studying genomic medicine can help inform day-to-day medical or clinical
practice, giving you a better understanding of what causes illness and
the effects of disease, which is of interest to a wide range of health
professionals. You can choose to study either single modules, a PgCert, a
PgDip or the full MSc, which can lead to a range of careers, including
in the NHS, the pharmaceutical industry and bioinformatics, or provide
preparation for a PhD.Of all the life sciences, genomics is one of the most dynamic areas. The
past 20 years have seen an explosion in our ability to explore the
structure, function and evolution of the human genome, with mapping and
editing of gene variants now possible due to technological advances,
including next-generation sequencing.
In seeking to identify how alterations to our genomes directly affect
disease and health, genomics is also leading a revolution in healthcare
by giving a better understanding of how drugs affect people differently
and thus allowing for focused, effective, treatment or ‘personalised
medicine’.
Under the umbrella term of genomic medicine, there are many different
areas that are covered. We look at the transcriptome – the total set of
RNA molecules which represents the genes active in a given organism or
particular cell type at a given point in time. Changes to the
transcriptome can both reflect and cause diseases such as cancer.
We also consider the ‘epigenome’, heritable chemical modifications to
DNA and DNA-associated proteins in the cell, which alter gene expression
as a result of natural development and tissue differentiation or in
response to disease or environmental exposures. In both instances, we
seek to identify how these changes directly affect disease and ill
health.
You will learn how recent technological advances have transformed how
genomic data is generated, analysed and presented; how bioinformatics is
enabling us to handle and make sense of big data and its impact across
healthcare. In doing so, you will consider its relevance to a range of
clinical scenarios, such as the spread of specific infections across
hospitals, the COVID-19 pandemic, and identification of biomarkers of
response to targeted therapies.
This master’s degree, awarded by St George’s University of London, is
taught in partnership with King’s College London. You will benefit from
the combined teaching and research expertise, and the comprehensive and
specialist resources provided by these two institutions, as both
specialist health universities, and two of the UK’s top research
universities.
Studying genomic medicine can help inform day-to-day medical or clinical
practice, giving you a better understanding of what causes illness and
the effects of disease, which is of interest to a wide range of health
professionals. You can choose to study either single modules, a PgCert, a
PgDip or the full MSc, which can lead to a range of careers, including
in the NHS, the pharmaceutical industry and bioinformatics, or provide
preparation for a PhD.
| 所属大学 | 伦敦国王学院 |
| 关联学科 | 医学 |
| 开学时间 | 9月 |
| 学制 | 1 年 |
| 项目网址 | https://www.kcl.ac.uk/study/postgraduate/taught-courses/genomic-medicine-msc-pg-dip-pg-cert |
申请要求
由伦敦大学圣乔治学院审理申请及提供教学。专业背景：相关的生物科学类专业。先修科目：含足够数量的genetics科目。语言成绩待确认，因为是合作课程KCL和圣乔治对语言要求由差异。
语言要求
IELTS
| 总分要求： | 7 |
| 分项要求： | 听力: 6.5 | 阅读: 6.5 | 写作: 6.5 | 口语: 6.5 |
TOEFL
| 总分要求： | 100 |
| 分项要求： | 听力: 23 | 阅读: 23 | 写作: 25 | 口语: 23 |
课程设置
| 中文课程名 | 英文课程名 |
|---|---|
| 所需模块 | Required modules |
| 人类遗传学和基因组学基础 | Fundamentals of Human Genetics and Genomics |
| 组学技术和技术; 它们在基因组医学中的应用 | Omics Techniques and Technologies; Their Application to Genomic Medicine |
| 基因组分析中的生物信息学，解释和数据质量保证 | Bioinformatics, Interpretation and Data Quality Assurance in Genome Analysis |
| 研究项目 (60学分或30学分) | Research Project (60 credit or 30 credit) |
| 癌症的分子病理学及其在癌症诊断，筛查和治疗中的应用 | Molecular Pathology of Cancer and Application in Cancer Diagnosis, Screening and Treatment |
| 药物基因组学和分层医疗保健 | Pharmacogenomics and Stratified Healthcare |
| 常见和罕见遗传性疾病的基因组学 | Genomics of Common and Rare Inherited Disease |
| 基因组学在传染病中的应用 | Application of Genomics in Infectious Disease |
| 心血管遗传学和基因组学 | Cardiovascular Genetics and Genomics |
| 基因组学咨询技能简介 | Introduction to Counselling Skills in Genomics |
| 应用基因组学中的伦理、法律和社会问题 | Ethical, legal and social issues in applied genomics |
| 高级生物信息学 | Advanced Bioinformatics |